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Lilly is also advancing a next-generation therapy, retatrutide, which combines GLP-1, GIP and glucagon and delivered 23% weight loss in a late-stage trial involving patients with knee osteoarthritis, alongside a more than 62% reduction in knee pain

Injections must be administered by trained professionals to avoid risks

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In patients with type 2 diabetes, treatment with semaglutide resulted in the following relative reductions in glucagon compared to placebo, fasting glucagon (8%), postprandial glucagon response (14 to 15%), and mean 24-hour glucagon concentration (12%)